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Salix’s strategy is to in-license late-stage or marketed proprietary therapeutic drugs, complete any required growth and regulatory submission of these merchandise, and market them via the Company’s one hundred fifty-member gastroenterology specialty gross sales and advertising group.
Mucosal production of arachidonic acid (AA) metabolites, each by means of the cyclooxygenase pathways, ie, prostanoids, and thru the lipoxygenase pathways, ie, leukotrienes (LTs) and hydroxyeicosatetraenoic acids (HETEs), is elevated in sufferers with chronic inflammatory bowel illness, and it is potential that mesalamine diminishes inflammation by blocking cyclooxygenase and inhibiting prostaglandin (PG) manufacturing in the colon.
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