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pentasa in stores delayed-launch tablets are indicated for the induction of remission in adults with active, mild to moderate ulcerative colitis and for the maintenance of remission of ulcerative colitis. While smoking has been associated to increased danger for exercise of disease in Crohn’s illness, it has demonstrated a protective effect in UC with the best threat of growing UC within the first 2 years after cessation of smoking (Stevenson and Korzenik 2003).
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Salix’s strategy is to in-license late-stage or marketed proprietary therapeutic drugs, complete any required growth and regulatory submission of these merchandise, and market them via the Company’s one hundred fifty-member gastroenterology specialty gross sales and advertising group.
Mucosal production of arachidonic acid (AA) metabolites, each by means of the cyclooxygenase pathways, ie, prostanoids, and thru the lipoxygenase pathways, ie, leukotrienes (LTs) and hydroxyeicosatetraenoic acids (HETEs), is elevated in sufferers with chronic inflammatory bowel illness, and it is potential that mesalamine diminishes inflammation by blocking cyclooxygenase and inhibiting prostaglandin (PG) manufacturing in the colon.
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